William's Harbour is located on the south side of Granby Island, at the mouth of Alexis Bay, about 35 km. east of Port Hope Simpson. In the late 1970's the residents of William's Harbour believed they would have a better chance of obtaining electricity, a small school and other services is they stayed in William's Harbour year-round.

Soon after, the community of Rexon's Harbour was abandoned with its residents residing in William's Harbour. Until the late 1970's William's Harbour was used only as a summer fishing station of nearby Rexon's Harbour and Port Hope Simpson. The Harbour was
believed to have been settled in the 1840's by the family of an Inuk named Samuel
Kibenook (now spelled Kippenhuck), and was later joined by his son-in-law William Russell. Since that time the majority of residents are Russell's and Larkhams.
There is currently a population of 59 with surnames such as Curl, Flynn, Kippenhuck, Larkham, Russell and Sooley.